Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 2868185..2868756 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag FOC64_RS13735 Protein ID WP_003401560.1
Coordinates 2868454..2868756 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag FOC64_RS13730 Protein ID WP_003401563.1
Coordinates 2868185..2868406 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS13715 2866090..2866998 - 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -
FOC64_RS13720 2866995..2867627 - 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
FOC64_RS13725 2867763..2868188 - 426 WP_003401566.1 PIN domain nuclease -
FOC64_RS13730 2868185..2868406 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
FOC64_RS13735 2868454..2868756 - 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
FOC64_RS13740 2868753..2868980 - 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
FOC64_RS13745 2869123..2870898 - 1776 WP_010886074.1 PE family protein -
FOC64_RS13750 2871077..2872474 + 1398 WP_003401544.1 sulfatase -
FOC64_RS13755 2872484..2873287 + 804 WP_003401540.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T158503 WP_003401560.1 NZ_CP054014:c2868756-2868454 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T158503 NZ_CP069657:183907-184014 [Escherichia coli O89m:H10]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT158503 WP_003401563.1 NZ_CP054014:c2868406-2868185 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT158503 NZ_CP069657:c183859-183793 [Escherichia coli O89m:H10]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References