Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2867763..2868406 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag FOC64_RS13725 Protein ID WP_003401566.1
Coordinates 2867763..2868188 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag FOC64_RS13730 Protein ID WP_003401563.1
Coordinates 2868185..2868406 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS13715 2866090..2866998 - 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -
FOC64_RS13720 2866995..2867627 - 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
FOC64_RS13725 2867763..2868188 - 426 WP_003401566.1 PIN domain nuclease Toxin
FOC64_RS13730 2868185..2868406 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
FOC64_RS13735 2868454..2868756 - 303 WP_003401560.1 toxin-antitoxin system toxin -
FOC64_RS13740 2868753..2868980 - 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
FOC64_RS13745 2869123..2870898 - 1776 WP_010886074.1 PE family protein -
FOC64_RS13750 2871077..2872474 + 1398 WP_003401544.1 sulfatase -
FOC64_RS13755 2872484..2873287 + 804 WP_003401540.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T158502 WP_003401566.1 NZ_CP054014:c2868188-2867763 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T158502 NZ_CP069650:c28688-28437 [Escherichia coli O7:H4]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT158502 WP_003401563.1 NZ_CP054014:c2868406-2868185 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT158502 NZ_CP069650:c28450-28223 [Escherichia coli O7:H4]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References