Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2536775..2537421 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag FOC64_RS12215 Protein ID WP_003403122.1
Coordinates 2537029..2537421 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag FOC64_RS12210 Protein ID WP_003403125.1
Coordinates 2536775..2537032 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS12175 2532093..2532404 - 312 WP_003403164.1 hypothetical protein -
FOC64_RS12180 2532461..2533222 + 762 WP_003403148.1 two-component system response regulator TcrA -
FOC64_RS12185 2533266..2533736 + 471 WP_003403144.1 HAMP domain-containing protein -
FOC64_RS12190 2533850..2534356 + 507 WP_003900973.1 two component system sensor kinase HK1 -
FOC64_RS12195 2534460..2534696 + 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FOC64_RS12200 2534693..2535106 + 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
FOC64_RS12205 2535357..2536592 + 1236 WP_003403128.1 ATP-binding protein -
FOC64_RS12210 2536775..2537032 + 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
FOC64_RS12215 2537029..2537421 + 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
FOC64_RS12220 2537473..2539023 - 1551 WP_003905349.1 MCE family protein -
FOC64_RS12225 2539028..2540236 - 1209 WP_003403114.1 virulence factor Mce family protein -
FOC64_RS12230 2540233..2541759 - 1527 WP_003403112.1 virulence factor Mce family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T158498 WP_003403122.1 NZ_CP054014:2537029-2537421 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T158498 NZ_CP069646:3962270-3962677 [Escherichia coli O7:H4]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGATGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTAGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT158498 WP_003403125.1 NZ_CP054014:2536775-2537032 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT158498 NZ_CP069646:3962023-3962289 [Escherichia coli O7:H4]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References