Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2528373..2529016 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag FOC64_RS12145 Protein ID WP_003403187.1
Coordinates 2528373..2528774 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag FOC64_RS12150 Protein ID WP_003403184.1
Coordinates 2528771..2529016 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS12115 2525331..2525936 - 606 WP_003898526.1 hypothetical protein -
FOC64_RS12120 2526078..2526299 + 222 WP_003898525.1 DUF4926 domain-containing protein -
FOC64_RS12125 2526351..2527508 + 1158 WP_003898524.1 hypothetical protein -
FOC64_RS12130 2527588..2527785 + 198 WP_003403191.1 hypothetical protein -
FOC64_RS12135 2527818..2527985 + 168 WP_077385191.1 DUF3800 domain-containing protein -
FOC64_RS12140 2528203..2528430 - 228 WP_003900974.1 hypothetical protein -
FOC64_RS12145 2528373..2528774 - 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC64_RS12150 2528771..2529016 - 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC64_RS12155 2529061..2529447 - 387 WP_003403180.1 hypothetical protein -
FOC64_RS12160 2529534..2530244 - 711 Protein_2398 transposase -
FOC64_RS12165 2530246..2530830 - 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FOC64_RS12170 2531071..2532021 - 951 WP_003900184.1 DUF1259 domain-containing protein -
FOC64_RS12175 2532093..2532404 - 312 WP_003403164.1 hypothetical protein -
FOC64_RS12180 2532461..2533222 + 762 WP_003403148.1 two-component system response regulator TcrA -
FOC64_RS12185 2533266..2533736 + 471 WP_003403144.1 HAMP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T158496 WP_003403187.1 NZ_CP054014:c2528774-2528373 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T158496 NZ_CP069646:3791559-3791855 [Escherichia coli O7:H4]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT158496 WP_003403184.1 NZ_CP054014:c2529016-2528771 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT158496 NZ_CP069646:3791857-3792252 [Escherichia coli O7:H4]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References