Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2520853..2521478 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FOC64_RS12090 Protein ID WP_003403218.1
Coordinates 2520853..2521254 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FOC64_RS12095 Protein ID WP_003403213.1
Coordinates 2521251..2521478 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS12065 2515943..2516890 - 948 WP_003403232.1 DUF732 domain-containing protein -
FOC64_RS12070 2516994..2518058 - 1065 WP_003898532.1 hypothetical protein -
FOC64_RS12075 2518453..2519544 - 1092 WP_003900977.1 galactokinase -
FOC64_RS12080 2519541..2520032 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FOC64_RS12085 2520029..2520724 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FOC64_RS12090 2520853..2521254 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FOC64_RS12095 2521251..2521478 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FOC64_RS12100 2521673..2521915 - 243 WP_003403210.1 hypothetical protein -
FOC64_RS12105 2521912..2522661 - 750 WP_003898528.1 hypothetical protein -
FOC64_RS12110 2522745..2525312 + 2568 WP_003901879.1 SEC-C domain-containing protein -
FOC64_RS12115 2525331..2525936 - 606 WP_003898526.1 hypothetical protein -
FOC64_RS12120 2526078..2526299 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T158495 WP_003403218.1 NZ_CP054014:c2521254-2520853 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T158495 NZ_CP069646:3727003-3727317 [Escherichia coli O7:H4]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT158495 WP_003403213.1 NZ_CP054014:c2521478-2521251 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT158495 NZ_CP069646:3727314-3727730 [Escherichia coli O7:H4]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References