Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2515201..2515850 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FOC64_RS12055 Protein ID WP_003403236.1
Coordinates 2515201..2515596 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FOC64_RS12060 Protein ID WP_003403235.1
Coordinates 2515596..2515850 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS12030 2510528..2512255 + 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -
FOC64_RS12035 2512348..2513499 + 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
FOC64_RS12040 2513571..2513978 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FOC64_RS12045 2513975..2514235 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC64_RS12050 2514367..2515107 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
FOC64_RS12055 2515201..2515596 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FOC64_RS12060 2515596..2515850 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FOC64_RS12065 2515943..2516890 - 948 WP_003403232.1 DUF732 domain-containing protein -
FOC64_RS12070 2516994..2518058 - 1065 WP_003898532.1 hypothetical protein -
FOC64_RS12075 2518453..2519544 - 1092 WP_003900977.1 galactokinase -
FOC64_RS12080 2519541..2520032 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FOC64_RS12085 2520029..2520724 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T158494 WP_003403236.1 NZ_CP054014:c2515596-2515201 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T158494 NZ_CP069646:3265484-3265591 [Escherichia coli O7:H4]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT158494 WP_003403235.1 NZ_CP054014:c2515850-2515596 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT158494 NZ_CP069646:c3265436-3265370 [Escherichia coli O7:H4]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References