Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-PHD |
| Location | 2513571..2514235 | Replicon | chromosome |
| Accession | NZ_CP054014 | ||
| Organism | Mycobacterium tuberculosis strain FDAARGOS_756 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P96917 |
| Locus tag | FOC64_RS12040 | Protein ID | WP_003403246.1 |
| Coordinates | 2513571..2513978 (-) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WF18 |
| Locus tag | FOC64_RS12045 | Protein ID | WP_003403244.1 |
| Coordinates | 2513975..2514235 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOC64_RS12030 | 2510528..2512255 | + | 1728 | WP_003901883.1 | exodeoxyribonuclease V subunit alpha | - |
| FOC64_RS12035 | 2512348..2513499 | + | 1152 | WP_003403248.1 | FIST C-terminal domain-containing protein | - |
| FOC64_RS12040 | 2513571..2513978 | - | 408 | WP_003403246.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| FOC64_RS12045 | 2513975..2514235 | - | 261 | WP_003403244.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FOC64_RS12050 | 2514367..2515107 | + | 741 | WP_003403239.1 | TVP38/TMEM64 family protein | - |
| FOC64_RS12055 | 2515201..2515596 | - | 396 | WP_003403236.1 | type II toxin-antitoxin system toxin ribonuclease C30 | - |
| FOC64_RS12060 | 2515596..2515850 | - | 255 | WP_003403235.1 | type II toxin-antitoxin system antitoxin VapB30 | - |
| FOC64_RS12065 | 2515943..2516890 | - | 948 | WP_003403232.1 | DUF732 domain-containing protein | - |
| FOC64_RS12070 | 2516994..2518058 | - | 1065 | WP_003898532.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 14376.37 Da Isoelectric Point: 4.3568
>T158493 WP_003403246.1 NZ_CP054014:c2513978-2513571 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV
Download Length: 408 bp
>T158493 NZ_CP069646:c2651152-2650604 [Escherichia coli O7:H4]
ATGTCTCACAATTCAGATATCTATAAACTTATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAACAGATTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGACGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGCAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTTCGGACAAAAATGGCCTCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGCCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA
ATGTCTCACAATTCAGATATCTATAAACTTATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAACAGATTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGACGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGCAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTTCGGACAAAAATGGCCTCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGCCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9492.84 Da Isoelectric Point: 11.9108
>AT158493 WP_003403244.1 NZ_CP054014:c2514235-2513975 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR
Download Length: 261 bp
>AT158493 NZ_CP069646:c2651648-2651175 [Escherichia coli O7:H4]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCACATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGATTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCACAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCTGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCAA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCACATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGATTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCACAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCTGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCAA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 3DBO |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 3DBO | |
| AlphaFold DB | A0A7U4BSE4 |