Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2478090..2478723 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag FOC64_RS11870 Protein ID WP_003403365.1
Coordinates 2478340..2478723 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag FOC64_RS11865 Protein ID WP_003403368.1
Coordinates 2478090..2478245 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS11835 2473207..2475570 - 2364 WP_003901895.1 arylsulfatase AtsD -
FOC64_RS11840 2475684..2475938 + 255 WP_003911263.1 antitoxin VapB7 -
FOC64_RS11845 2475935..2476372 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FOC64_RS11850 2476482..2476727 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FOC64_RS11855 2476714..2477022 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FOC64_RS11860 2477298..2478014 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FOC64_RS11865 2478090..2478245 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC64_RS11870 2478340..2478723 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
FOC64_RS11875 2479111..2480121 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FOC64_RS11880 2480202..2481707 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FOC64_RS11885 2481778..2482473 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
FOC64_RS11890 2482466..2482858 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
FOC64_RS11895 2482895..2483431 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T158492 WP_003403365.1 NZ_CP054014:2478340-2478723 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T158492 NZ_CP069646:c2520462-2520289 [Escherichia coli O7:H4]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT158492 WP_003403368.1 NZ_CP054014:2478090-2478245 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT158492 NZ_CP069646:c2520786-2520490 [Escherichia coli O7:H4]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References