Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 2475935..2476727 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FOC64_RS11845 Protein ID WP_003403386.1
Coordinates 2475935..2476372 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag FOC64_RS11850 Protein ID WP_003403381.1
Coordinates 2476482..2476727 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS11820 2472398..2472571 - 174 WP_003898549.1 hypothetical protein -
FOC64_RS11825 2472568..2472906 - 339 WP_003403405.1 PIN domain-containing protein -
FOC64_RS11830 2472818..2473144 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC64_RS11835 2473207..2475570 - 2364 WP_003901895.1 arylsulfatase AtsD -
FOC64_RS11840 2475684..2475938 + 255 WP_003911263.1 antitoxin VapB7 -
FOC64_RS11845 2475935..2476372 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC64_RS11850 2476482..2476727 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
FOC64_RS11855 2476714..2477022 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FOC64_RS11860 2477298..2478014 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FOC64_RS11865 2478090..2478245 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FOC64_RS11870 2478340..2478723 + 384 WP_003403365.1 ribonuclease VapC6 -
FOC64_RS11875 2479111..2480121 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FOC64_RS11880 2480202..2481707 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T158490 WP_003403386.1 NZ_CP054014:2475935-2476372 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T158490 NZ_CP069646:2274922-2275179 [Escherichia coli O7:H4]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT158490 WP_003403381.1 NZ_CP054014:2476482-2476727 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT158490 NZ_CP069646:2275191-2275736 [Escherichia coli O7:H4]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References