Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2000509..2001140 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FOC64_RS09505 Protein ID WP_003405820.1
Coordinates 2000829..2001140 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FOC64_RS09500 Protein ID WP_003405836.1
Coordinates 2000509..2000829 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS09475 1995705..1996343 + 639 WP_003898730.1 lipid droplet-associated protein -
FOC64_RS09480 1996340..1997587 + 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
FOC64_RS09485 1997577..1997834 + 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
FOC64_RS09490 1997844..1998956 + 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
FOC64_RS09495 1998974..2000499 - 1526 Protein_1877 carboxylesterase/lipase family protein -
FOC64_RS09500 2000509..2000829 + 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
FOC64_RS09505 2000829..2001140 + 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
FOC64_RS09510 2001252..2002409 + 1158 WP_003898727.1 AI-2E family transporter -
FOC64_RS09515 2002416..2003060 - 645 WP_003915494.1 DUF4245 domain-containing protein -
FOC64_RS09520 2003116..2004204 + 1089 WP_003898726.1 class II fructose-bisphosphatase -
FOC64_RS09525 2004235..2005659 + 1425 WP_003405805.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T158485 WP_003405820.1 NZ_CP054014:2000829-2001140 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T158485 NZ_CP069646:927832-927939 [Escherichia coli O7:H4]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT158485 WP_003405836.1 NZ_CP054014:2000509-2000829 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT158485 NZ_CP069646:c927785-927719 [Escherichia coli O7:H4]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References