Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1991816..1992384 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag FOC64_RS09450 Protein ID WP_003405865.1
Coordinates 1991816..1992190 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag FOC64_RS09455 Protein ID WP_003405863.1
Coordinates 1992187..1992384 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS09415 1988296..1988790 + 495 WP_003405876.1 adenylate/guanylate cyclase domain-containing protein -
FOC64_RS09420 1988888..1989097 - 210 WP_003911400.1 hypothetical protein -
FOC64_RS09425 1989119..1989829 + 711 WP_003911399.1 hypothetical protein -
FOC64_RS09430 1989844..1990167 - 324 WP_003405871.1 antibiotic biosynthesis monooxygenase -
FOC64_RS09435 1990410..1990685 + 276 WP_003405867.1 hypothetical protein -
FOC64_RS09440 1990612..1990797 - 186 WP_003901093.1 hypothetical protein -
FOC64_RS09445 1990915..1991613 - 699 WP_003898733.1 hypothetical protein -
FOC64_RS09450 1991816..1992190 - 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC64_RS09455 1992187..1992384 - 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC64_RS09460 1992472..1993545 - 1074 WP_003898732.1 redox-regulated ATPase YchF -
FOC64_RS09465 1993608..1994591 + 984 WP_003898731.1 hypothetical protein -
FOC64_RS09470 1994608..1995615 - 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
FOC64_RS09475 1995705..1996343 + 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T158484 WP_003405865.1 NZ_CP054014:c1992190-1991816 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T158484 NZ_CP069646:927297-927404 [Escherichia coli O7:H4]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT158484 WP_003405863.1 NZ_CP054014:c1992384-1992187 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT158484 NZ_CP069646:c927250-927184 [Escherichia coli O7:H4]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TH08

Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References