Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1848318..1849006 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag FOC64_RS08810 Protein ID WP_003406304.1
Coordinates 1848318..1848749 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag FOC64_RS08815 Protein ID WP_003406302.1
Coordinates 1848746..1849006 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS08785 1844145..1844414 + 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC64_RS08790 1844411..1844704 + 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
FOC64_RS08795 1844761..1845591 + 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
FOC64_RS08800 1845672..1846532 - 861 WP_003900301.1 hypothetical protein -
FOC64_RS08805 1846712..1848295 + 1584 WP_009940130.1 PE family protein -
FOC64_RS08810 1848318..1848749 - 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC64_RS08815 1848746..1849006 - 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
FOC64_RS08820 1849082..1850071 - 990 WP_003406301.1 malate dehydrogenase -
FOC64_RS08825 1850242..1851342 + 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
FOC64_RS08830 1851419..1852600 - 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
FOC64_RS08835 1852605..1853429 - 825 WP_003900298.1 trehalose ABC transporter permease SugB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T158483 WP_003406304.1 NZ_CP054014:c1848749-1848318 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T158483 NZ_CP069646:926762-926869 [Escherichia coli O7:H4]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT158483 WP_003406302.1 NZ_CP054014:c1849006-1848746 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT158483 NZ_CP069646:c926715-926649 [Escherichia coli O7:H4]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References