Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1464698..1465326 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag FOC64_RS07105 Protein ID WP_003407786.1
Coordinates 1464698..1465102 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WLU3
Locus tag FOC64_RS07110 Protein ID WP_003407785.1
Coordinates 1465108..1465326 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS07095 1460649..1462946 + 2298 WP_003407790.1 malto-oligosyltrehalose synthase -
FOC64_RS07100 1462939..1464681 + 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
FOC64_RS07105 1464698..1465102 - 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
FOC64_RS07110 1465108..1465326 - 219 WP_003407785.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC64_RS07115 1465364..1466653 - 1290 WP_003407781.1 threonine ammonia-lyase -
FOC64_RS07120 1466688..1467134 - 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
FOC64_RS07125 1467144..1468337 - 1194 WP_003901197.1 MMPL family transporter -
FOC64_RS07130 1468476..1469084 - 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
FOC64_RS07135 1469152..1469529 - 378 WP_003407771.1 fumarate reductase subunit FrdD -
FOC64_RS07140 1469526..1469906 - 381 WP_003407768.1 fumarate reductase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-49)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T158479 WP_003407786.1 NZ_CP054014:c1465102-1464698 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T158479 NZ_CP069643:1791-2075 [Escherichia coli]
ATGAGCTATAACCTTGAATTTGATCCCCGAGCCCTGAAGGAATGGCGCAAGCTCGGGGATGATGTCCGTCTGCAGTTCAA
GAAAAAACTCGAGCAGGTTCTACAACACCCGCGGATCGATAAAAATCGCCTGCGAGAGCTGCATGACTGCTACAAAATCA
AGCTCCGTGCATCCGGTTATCGCTTGGTCTATCAGGTTCGCGATCAAACCATTACGGTATTCGTGGTGGCGGTCGGTAAG
CGCGAGCGTTCTGCCGCTTACGATGCGGCCGATAAACGCTTATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8209.32 Da        Isoelectric Point: 4.5600

>AT158479 WP_003407785.1 NZ_CP054014:c1465326-1465108 [Mycobacterium tuberculosis]
VYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 219 bp

>AT158479 NZ_CP069643:1559-1801 [Escherichia coli]
ATGGCCACGATTAATATTCGGATCGATGACGAGCTGAAAAGCCGCTCTTATGCCGCACTGGAAAAGCTGGGCGTAACGCC
GTCCGAGGTTCTGCGCCAAACACTGGAATATGTGGCCCAAAGCGGACGTTTGCCGTTCCAGCAGGTTTTGCTGACCGAGG
ATGATGCCGATTTGATGGCTATCGTTCGGGATCGTCTGGAAAACCCACAGGCGGGCGTAAAGGTGTCACTGGATGAGCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
PDB 6A7V
AlphaFold DB P9WLU3

References