158478

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1291654..1292267 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FOC64_RS06360 Protein ID WP_003408465.1
Coordinates 1291878..1292267 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FOC64_RS06355 Protein ID WP_003408469.1
Coordinates 1291654..1291881 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS06335 1287546..1288256 + 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -
FOC64_RS06340 1288246..1288665 + 420 WP_003408483.1 hypothetical protein -
FOC64_RS06345 1288708..1289955 - 1248 WP_003408476.1 serine hydrolase -
FOC64_RS06350 1289952..1291436 - 1485 WP_003408473.1 carboxylase -
FOC64_RS06355 1291654..1291881 + 228 WP_003408469.1 antitoxin Antitoxin
FOC64_RS06360 1291878..1292267 + 390 WP_003408465.1 PIN domain-containing protein Toxin
FOC64_RS06370 1292877..1293656 - 780 WP_003408460.1 IclR family transcriptional regulator -
FOC64_RS06375 1293670..1294488 - 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FOC64_RS06380 1294541..1294891 - 351 WP_003898986.1 cupin domain-containing protein -
FOC64_RS06385 1294891..1295721 - 831 WP_003408448.1 cyclase family protein -
FOC64_RS06390 1295724..1296638 - 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T158478 WP_003408465.1 NZ_CP054014:1291878-1292267 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T158478 NZ_CP069642:c4881537-4881430 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT158478 WP_003408469.1 NZ_CP054014:1291654-1291881 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT158478 NZ_CP069642:4881593-4881654 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References