Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1038787..1039331 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FOC64_RS05160 Protein ID WP_003409896.1
Coordinates 1039035..1039331 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FOC64_RS05155 Protein ID WP_003409899.1
Coordinates 1038787..1039038 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS05130 1034514..1035311 - 798 WP_003899101.1 ABC transporter permease -
FOC64_RS05135 1036210..1037430 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FOC64_RS05140 1037463..1037735 + 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC64_RS05145 1037739..1038146 + 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FOC64_RS05150 1038306..1038800 - 495 WP_003899099.1 hypothetical protein -
FOC64_RS05155 1038787..1039038 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FOC64_RS05160 1039035..1039331 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC64_RS05165 1039380..1039994 + 615 WP_003901296.1 hypothetical protein -
FOC64_RS05170 1039883..1040428 - 546 WP_003409891.1 SecB-like chaperone -
FOC64_RS05175 1040425..1040874 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FOC64_RS05180 1040916..1041293 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FOC64_RS05185 1041268..1041789 + 522 WP_003904745.1 hypothetical protein -
FOC64_RS05190 1041763..1042074 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FOC64_RS05195 1042071..1042286 - 216 WP_003409878.1 antitoxin -
FOC64_RS05200 1042526..1042822 + 297 WP_003409877.1 hypothetical protein -
FOC64_RS05205 1042823..1043014 + 192 WP_003409876.1 hypothetical protein -
FOC64_RS05210 1043035..1043937 + 903 WP_003899097.1 hypothetical protein -
FOC64_RS05215 1043948..1044298 + 351 WP_003409871.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T158474 WP_003409896.1 NZ_CP054014:1039035-1039331 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T158474 NZ_CP069642:3547830-3548144 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT158474 WP_003409899.1 NZ_CP054014:1038787-1039038 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT158474 NZ_CP069642:3547594-3547827 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References