Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1012415..1013103 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag FOC64_RS05010 Protein ID WP_003409958.1
Coordinates 1012684..1013103 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag FOC64_RS05005 Protein ID WP_003409968.1
Coordinates 1012415..1012675 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS04980 1007906..1008505 - 600 WP_003910883.1 L-lysine exporter -
FOC64_RS04985 1008614..1009525 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FOC64_RS04990 1009610..1009840 - 231 WP_003409980.1 DUF167 domain-containing protein -
FOC64_RS04995 1009955..1010608 + 654 WP_003409976.1 cutinase Cfp21 -
FOC64_RS05000 1010596..1012272 - 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
FOC64_RS05005 1012415..1012675 + 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC64_RS05010 1012684..1013103 + 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC64_RS05015 1013328..1014296 + 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
FOC64_RS05020 1014487..1015173 + 687 WP_003409954.1 immunoprotective protein Mpt64 -
FOC64_RS05025 1015352..1016797 + 1446 WP_003899115.1 APC family permease -
FOC64_RS05030 1016760..1017608 - 849 WP_003901306.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T158473 WP_003409958.1 NZ_CP054014:1012684-1013103 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T158473 NZ_CP069642:c3510895-3510743 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT158473 WP_003409968.1 NZ_CP054014:1012415-1012675 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT158473 NZ_CP069642:3510944-3511001 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References