Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 1004879..1005777 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FOC64_RS04965 Protein ID WP_003410001.1
Coordinates 1005217..1005777 (+) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FOC64_RS04960 Protein ID WP_003410003.1
Coordinates 1004879..1005220 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS04925 1000532..1000888 + 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
FOC64_RS04930 1000941..1001213 + 273 WP_003410017.1 DUF1490 family protein -
FOC64_RS04935 1001210..1003525 + 2316 WP_003899120.1 cation transporter ATPase CptG -
FOC64_RS04940 1003625..1003873 + 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FOC64_RS04945 1003867..1004211 + 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FOC64_RS04950 1004300..1004635 + 336 WP_003410009.1 dehydrogenase -
FOC64_RS04955 1004536..1004793 - 258 WP_003410006.1 hypothetical protein -
FOC64_RS04960 1004879..1005220 + 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FOC64_RS04965 1005217..1005777 + 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FOC64_RS04970 1006297..1006836 - 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FOC64_RS04975 1007062..1007490 - 429 WP_003409992.1 cellulose-binding protein -
FOC64_RS04980 1007906..1008505 - 600 WP_003910883.1 L-lysine exporter -
FOC64_RS04985 1008614..1009525 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FOC64_RS04990 1009610..1009840 - 231 WP_003409980.1 DUF167 domain-containing protein -
FOC64_RS04995 1009955..1010608 + 654 WP_003409976.1 cutinase Cfp21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T158472 WP_003410001.1 NZ_CP054014:1005217-1005777 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T158472 NZ_CP069642:3442280-3442567 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT158472 WP_003410003.1 NZ_CP054014:1004879-1005220 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT158472 NZ_CP069642:3442554-3442856 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References