Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 979846..980487 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag FOC64_RS04845 Protein ID WP_003410075.1
Coordinates 979846..980244 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WLM7
Locus tag FOC64_RS04850 Protein ID WP_003899127.1
Coordinates 980245..980487 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS04810 974852..975127 - 276 WP_016330411.1 hypothetical protein -
FOC64_RS04815 975445..976701 + 1257 WP_003902247.1 HNH endonuclease -
FOC64_RS04820 976829..977419 - 591 WP_003899131.1 IS110 family transposase -
FOC64_RS04825 977373..978020 - 648 WP_071854215.1 transposase -
FOC64_RS04830 978081..978260 + 180 Protein_951 hypothetical protein -
FOC64_RS04835 978697..979191 - 495 WP_009940645.1 DUF1398 domain-containing protein -
FOC64_RS04840 979232..979663 + 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC64_RS04845 979846..980244 - 399 WP_003410075.1 PIN domain nuclease Toxin
FOC64_RS04850 980245..980487 - 243 WP_003899127.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC64_RS04855 980575..981900 + 1326 WP_003410070.1 DUF4143 domain-containing protein -
FOC64_RS04860 982089..982433 + 345 WP_003410065.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-48)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T158470 WP_003410075.1 NZ_CP054014:c980244-979846 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T158470 NZ_CP069642:3172061-3172234 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8851.73 Da        Isoelectric Point: 4.1621

>AT158470 WP_003899127.1 NZ_CP054014:c980487-980245 [Mycobacterium tuberculosis]
VYSGVVSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 243 bp

>AT158470 NZ_CP069642:3171737-3172033 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
PDB 4CHG
AlphaFold DB A0A045JPF9

References