Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 827898..828427 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FOC64_RS04135 Protein ID WP_003411124.1
Coordinates 828110..828427 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FOC64_RS04130 Protein ID WP_003411127.1
Coordinates 827898..828113 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS04100 823005..823784 + 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -
FOC64_RS04105 823846..824502 + 657 WP_003411133.1 cell division protein SepF -
FOC64_RS04110 824664..824954 + 291 WP_003900476.1 YggT family protein -
FOC64_RS04115 825222..826004 + 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FOC64_RS04120 826099..826455 + 357 WP_003411130.1 hypothetical protein -
FOC64_RS04125 826585..827643 - 1059 WP_003411129.1 hypothetical protein -
FOC64_RS04130 827898..828113 + 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FOC64_RS04135 828110..828427 + 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC64_RS04145 829014..830360 + 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FOC64_RS04150 830408..830938 + 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FOC64_RS04155 830943..832016 - 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
FOC64_RS04160 832052..832333 - 282 WP_003411112.1 hypothetical protein -
FOC64_RS04165 832330..833406 - 1077 WP_003411110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T158466 WP_003411124.1 NZ_CP054014:828110-828427 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T158466 NZ_CP069642:1802210-1802587 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT158466 WP_003411127.1 NZ_CP054014:827898-828113 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT158466 NZ_CP069642:1801753-1802121 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References