Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 303165..303879 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FOC64_RS01670 Protein ID WP_003413460.1
Coordinates 303165..303605 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FOC64_RS01675 Protein ID WP_003413456.1
Coordinates 303592..303879 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS01645 299077..299751 - 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -
FOC64_RS01650 299879..300778 + 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FOC64_RS01655 300807..301652 + 846 WP_003413466.1 acyl-CoA thioesterase II -
FOC64_RS01660 301660..302256 + 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FOC64_RS01665 302389..303144 + 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FOC64_RS01670 303165..303605 - 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC64_RS01675 303592..303879 - 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FOC64_RS01680 303990..305561 - 1572 WP_003899392.1 polyamine aminopropyltransferase -
FOC64_RS01685 305558..305959 - 402 WP_003899391.1 DUF350 domain-containing protein -
FOC64_RS01690 306041..306472 - 432 WP_003899390.1 DUF4247 domain-containing protein -
FOC64_RS01695 306469..306963 - 495 WP_003413444.1 DUF2617 family protein -
FOC64_RS01700 306974..307594 - 621 WP_003413441.1 DUF4178 domain-containing protein -
FOC64_RS01705 307811..308215 - 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
FOC64_RS01710 308212..308457 - 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T158460 WP_003413460.1 NZ_CP054014:c303605-303165 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T158460 NZ_CP069642:c398025-397923 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT158460 WP_003413456.1 NZ_CP054014:c303879-303592 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT158460 NZ_CP069642:397885-398153 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References