Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3980787..3981391 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag FOC65_RS18660 Protein ID WP_003414492.1
Coordinates 3980787..3981179 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P71622
Locus tag FOC65_RS18665 Protein ID WP_003912003.1
Coordinates 3981176..3981391 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS18630 3975937..3976659 - 723 WP_003912014.1 CRISPR-associated endoribonuclease Cas6 -
FOC65_RS18635 3977059..3977604 - 546 WP_003913758.1 DUF1802 family protein -
FOC65_RS18640 3977876..3978760 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FOC65_RS18645 3978763..3979650 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
FOC65_RS18650 3979955..3980500 - 546 WP_003899500.1 DUF1802 family protein -
FOC65_RS18655 3980497..3980766 - 270 WP_003414489.1 DUF2277 family protein -
FOC65_RS18660 3980787..3981179 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC65_RS18665 3981176..3981391 - 216 WP_003912003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC65_RS18670 3981438..3982187 + 750 WP_003414497.1 enoyl-CoA hydratase -
FOC65_RS18675 3982266..3983348 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
FOC65_RS18680 3983341..3984651 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
FOC65_RS18685 3984654..3985481 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
FOC65_RS18690 3985478..3986389 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T158448 WP_003414492.1 NZ_CP054013:c3981179-3980787 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T158448 NZ_CP069639:3172061-3172234 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7483.50 Da        Isoelectric Point: 4.9732

>AT158448 WP_003912003.1 NZ_CP054013:c3981391-3981176 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAADDDELFTTGVSWNVS

Download         Length: 216 bp

>AT158448 NZ_CP069639:3171737-3172033 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB P71622

References