Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN_Sll0205-like-Phd |
Location | 3980787..3981391 | Replicon | chromosome |
Accession | NZ_CP054013 | ||
Organism | Mycobacterium tuberculosis strain FDAARGOS_757 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P71623 |
Locus tag | FOC65_RS18660 | Protein ID | WP_003414492.1 |
Coordinates | 3980787..3981179 (-) | Length | 131 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P71622 |
Locus tag | FOC65_RS18665 | Protein ID | WP_003912003.1 |
Coordinates | 3981176..3981391 (-) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOC65_RS18630 | 3975937..3976659 | - | 723 | WP_003912014.1 | CRISPR-associated endoribonuclease Cas6 | - |
FOC65_RS18635 | 3977059..3977604 | - | 546 | WP_003913758.1 | DUF1802 family protein | - |
FOC65_RS18640 | 3977876..3978760 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
FOC65_RS18645 | 3978763..3979650 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | - |
FOC65_RS18650 | 3979955..3980500 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
FOC65_RS18655 | 3980497..3980766 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
FOC65_RS18660 | 3980787..3981179 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FOC65_RS18665 | 3981176..3981391 | - | 216 | WP_003912003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
FOC65_RS18670 | 3981438..3982187 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
FOC65_RS18675 | 3982266..3983348 | - | 1083 | WP_003414499.1 | ABC transporter ATP-binding protein | - |
FOC65_RS18680 | 3983341..3984651 | - | 1311 | WP_003414501.1 | ABC transporter substrate-binding protein | - |
FOC65_RS18685 | 3984654..3985481 | - | 828 | WP_003414504.1 | carbohydrate ABC transporter permease | - |
FOC65_RS18690 | 3985478..3986389 | - | 912 | WP_003414505.1 | sugar ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14610.74 Da Isoelectric Point: 6.7594
>T158448 WP_003414492.1 NZ_CP054013:c3981179-3980787 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
Download Length: 393 bp
>T158448 NZ_CP069639:3172061-3172234 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 72 a.a. Molecular weight: 7483.50 Da Isoelectric Point: 4.9732
>AT158448 WP_003912003.1 NZ_CP054013:c3981391-3981176 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAADDDELFTTGVSWNVS
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAADDDELFTTGVSWNVS
Download Length: 216 bp
>AT158448 NZ_CP069639:3171737-3172033 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BWM8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | P71622 |