Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3954334..3954904 | Replicon | chromosome |
Accession | NZ_CP054013 | ||
Organism | Mycobacterium tuberculosis strain FDAARGOS_757 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | FOC65_RS18515 | Protein ID | WP_003414166.1 |
Coordinates | 3954334..3954690 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | FOC65_RS18520 | Protein ID | WP_003901465.1 |
Coordinates | 3954674..3954904 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOC65_RS18495 | 3949786..3951474 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
FOC65_RS18500 | 3951478..3951804 | - | 327 | WP_003414157.1 | hypothetical protein | - |
FOC65_RS18505 | 3951935..3952564 | + | 630 | WP_003414158.1 | DUF3558 family protein | - |
FOC65_RS18510 | 3952583..3954232 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
FOC65_RS18515 | 3954334..3954690 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
FOC65_RS18520 | 3954674..3954904 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
FOC65_RS18525 | 3954947..3955990 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
FOC65_RS18530 | 3956181..3956456 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
FOC65_RS18535 | 3956632..3956886 | - | 255 | WP_003917684.1 | hypothetical protein | - |
FOC65_RS18540 | 3957034..3957438 | + | 405 | WP_009938577.1 | hypothetical protein | - |
FOC65_RS18545 | 3957435..3957626 | + | 192 | WP_003414184.1 | hypothetical protein | - |
FOC65_RS18550 | 3957825..3958979 | + | 1155 | WP_003911958.1 | DDE-type integrase/transposase/recombinase | - |
FOC65_RS18555 | 3959213..3959470 | + | 258 | WP_003899489.1 | hypothetical protein | - |
FOC65_RS18560 | 3959575..3959886 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T158446 WP_003414166.1 NZ_CP054013:c3954690-3954334 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T158446 NZ_CP069639:c2447851-2447744 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT158446 WP_003901465.1 NZ_CP054013:c3954904-3954674 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT158446 NZ_CP069639:2447899-2447965 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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