Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3712321..3713030 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FOC65_RS17200 Protein ID WP_003413164.1
Coordinates 3712321..3712734 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FOC65_RS17205 Protein ID WP_003413167.1
Coordinates 3712773..3713030 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS17170 3707374..3708579 - 1206 WP_003413027.1 chorismate synthase -
FOC65_RS17175 3708594..3709001 + 408 WP_003413029.1 hypothetical protein -
FOC65_RS17180 3709297..3710508 + 1212 WP_009936235.1 alpha/beta hydrolase family protein -
FOC65_RS17185 3710635..3711294 + 660 WP_003900846.1 LppA family lipoprotein -
FOC65_RS17190 3711291..3711953 + 663 WP_003900848.1 hypothetical protein -
FOC65_RS17195 3711950..3712228 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FOC65_RS17200 3712321..3712734 + 414 WP_003413164.1 PIN domain nuclease Toxin
FOC65_RS17205 3712773..3713030 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FOC65_RS17210 3713027..3713404 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FOC65_RS17215 3713420..3713794 - 375 WP_003413177.1 hypothetical protein -
FOC65_RS17220 3713894..3714289 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FOC65_RS17225 3714286..3714531 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FOC65_RS17230 3714942..3715361 - 420 WP_003413190.1 A24 family peptidase -
FOC65_RS17235 3715373..3716182 - 810 WP_003413193.1 shikimate dehydrogenase -
FOC65_RS17240 3716179..3717432 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FOC65_RS17245 3717425..3717937 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T158439 WP_003413164.1 NZ_CP054013:3712321-3712734 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T158439 NZ_CP069639:727100-727474 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT158439 WP_003413167.1 NZ_CP054013:3712773-3713030 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT158439 NZ_CP069639:726643-727011 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References