Detailed information of TA system TA158438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3698434..3699074
• Replicon: chromosome
• Accession: NZ_CP054013
• Organism: Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: FOC65_RS17115
• Protein ID: WP_003412970.1
• Coordinates: 3698434..3698853 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: FOC65_RS17120
• Protein ID: WP_003412975.1
• Coordinates: 3698850..3699074 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC65_RS17085	3694019..3694741	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
FOC65_RS17090	3695258..3695485	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
FOC65_RS17095	3695482..3695883	+	402	WP_003412963.1	PIN domain-containing protein	-
FOC65_RS17100	3695918..3696838	-	921	WP_003412965.1	restriction endonuclease	-
FOC65_RS17105	3697179..3697424	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FOC65_RS17110	3697483..3698433	+	951	WP_003911916.1	Lsr2 family protein	-
FOC65_RS17115	3698434..3698853	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC65_RS17120	3698850..3699074	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
FOC65_RS17125	3699105..3701948	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
FOC65_RS17130	3702020..3702421	-	402	WP_003412981.1	hypothetical protein	-
FOC65_RS17135	3702421..3702891	-	471	WP_003899364.1	transcription antitermination factor NusB	-
FOC65_RS17140	3702894..3703457	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T158438 WP_003412970.1 NZ_CP054013:c3698853-3698434 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T158438 NZ_CP069639:c398025-397923 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT158438 WP_003412975.1 NZ_CP054013:c3699074-3698850 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT158438 NZ_CP069639:397885-398153 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09