Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 3244294..3244823 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FOC65_RS15000 Protein ID WP_003411124.1
Coordinates 3244294..3244611 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FOC65_RS15005 Protein ID WP_003411127.1
Coordinates 3244608..3244823 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS14970 3239431..3240507 + 1077 WP_003411110.1 hypothetical protein -
FOC65_RS14975 3240504..3240785 + 282 WP_003411112.1 hypothetical protein -
FOC65_RS14980 3240821..3241894 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
FOC65_RS14985 3241899..3242429 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FOC65_RS14990 3242477..3243823 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FOC65_RS15000 3244294..3244611 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC65_RS15005 3244608..3244823 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FOC65_RS15010 3245078..3246136 + 1059 WP_003411129.1 hypothetical protein -
FOC65_RS15015 3246266..3246622 - 357 WP_003411130.1 hypothetical protein -
FOC65_RS15020 3246717..3247499 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FOC65_RS15025 3247767..3248057 - 291 WP_003900476.1 YggT family protein -
FOC65_RS15030 3248219..3248875 - 657 WP_003411133.1 cell division protein SepF -
FOC65_RS15035 3248941..3249717 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T158436 WP_003411124.1 NZ_CP054013:c3244611-3244294 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T158436 NZ_CP069639:c68761-68483 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT158436 WP_003411127.1 NZ_CP054013:c3244823-3244608 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT158436 NZ_CP069639:c68483-68199 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References