158434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 3162932..3163568 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag FOC65_RS14600 Protein ID WP_003410654.1
Coordinates 3163158..3163568 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag FOC65_RS14595 Protein ID WP_003410651.1
Coordinates 3162932..3163165 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS14580 3158380..3158781 + 402 WP_009937711.1 metal ABC transporter permease -
FOC65_RS14585 3158782..3159186 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
FOC65_RS14590 3159270..3162854 - 3585 WP_003410648.1 cobaltochelatase subunit CobN -
FOC65_RS14595 3162932..3163165 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
FOC65_RS14600 3163158..3163568 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
FOC65_RS14605 3163552..3164643 + 1092 WP_003900454.1 precorrin-3B synthase -
FOC65_RS14610 3164653..3165279 + 627 WP_003410658.1 precorrin-8X methylmutase -
FOC65_RS14615 3165276..3166802 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
FOC65_RS14620 3166748..3167971 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T158434 WP_003410654.1 NZ_CP054013:3163158-3163568 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

>T158434 NZ_CP069636:c4881536-4881429 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT158434 WP_003410651.1 NZ_CP054013:3162932-3163165 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp

>AT158434 NZ_CP069636:4881592-4881653 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BV50

References