Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 3074840..3075738 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FOC65_RS14200 Protein ID WP_003410001.1
Coordinates 3074840..3075400 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FOC65_RS14205 Protein ID WP_003410003.1
Coordinates 3075397..3075738 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS14170 3070009..3070662 - 654 WP_003409976.1 cutinase Cfp21 -
FOC65_RS14175 3070777..3071007 + 231 WP_003409980.1 DUF167 domain-containing protein -
FOC65_RS14180 3071092..3072003 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FOC65_RS14185 3072112..3072711 + 600 WP_003409989.1 L-lysine exporter -
FOC65_RS14190 3073127..3073555 + 429 WP_003409992.1 cellulose-binding protein -
FOC65_RS14195 3073781..3074320 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FOC65_RS14200 3074840..3075400 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FOC65_RS14205 3075397..3075738 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FOC65_RS14210 3075824..3076081 + 258 WP_003410006.1 hypothetical protein -
FOC65_RS14215 3075982..3076317 - 336 WP_003410009.1 dehydrogenase -
FOC65_RS14220 3076406..3076750 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FOC65_RS14225 3076744..3076992 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FOC65_RS14230 3077092..3079407 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FOC65_RS14235 3079404..3079676 - 273 WP_003410017.1 DUF1490 family protein -
FOC65_RS14240 3079729..3080085 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T158430 WP_003410001.1 NZ_CP054013:c3075400-3074840 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T158430 NZ_CP069636:3547829-3548143 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT158430 WP_003410003.1 NZ_CP054013:c3075738-3075397 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT158430 NZ_CP069636:3547593-3547826 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References