Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3067514..3068202 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag FOC65_RS14155 Protein ID WP_003409958.1
Coordinates 3067514..3067933 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag FOC65_RS14160 Protein ID WP_003409968.1
Coordinates 3067942..3068202 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS14135 3063009..3063857 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
FOC65_RS14140 3063820..3065265 - 1446 WP_003899115.1 APC family permease -
FOC65_RS14145 3065444..3066130 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
FOC65_RS14150 3066321..3067289 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
FOC65_RS14155 3067514..3067933 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC65_RS14160 3067942..3068202 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC65_RS14165 3068345..3070021 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
FOC65_RS14170 3070009..3070662 - 654 WP_003409976.1 cutinase Cfp21 -
FOC65_RS14175 3070777..3071007 + 231 WP_003409980.1 DUF167 domain-containing protein -
FOC65_RS14180 3071092..3072003 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FOC65_RS14185 3072112..3072711 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T158429 WP_003409958.1 NZ_CP054013:c3067933-3067514 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T158429 NZ_CP069636:c3510894-3510742 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT158429 WP_003409968.1 NZ_CP054013:c3068202-3067942 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT158429 NZ_CP069636:3510943-3511000 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References