Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 3045781..3046325 | Replicon | chromosome |
| Accession | NZ_CP054013 | ||
| Organism | Mycobacterium tuberculosis strain FDAARGOS_757 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FOC65_RS14035 | Protein ID | WP_003409896.1 |
| Coordinates | 3045781..3046077 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FOC65_RS14040 | Protein ID | WP_003409899.1 |
| Coordinates | 3046074..3046325 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOC65_RS13980 | 3040814..3041164 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| FOC65_RS13985 | 3041175..3042077 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| FOC65_RS13990 | 3042098..3042289 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FOC65_RS13995 | 3042290..3042586 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FOC65_RS14000 | 3042826..3043041 | + | 216 | WP_003409878.1 | antitoxin | - |
| FOC65_RS14005 | 3043038..3043349 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FOC65_RS14010 | 3043323..3043844 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FOC65_RS14015 | 3043819..3044196 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FOC65_RS14020 | 3044238..3044687 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FOC65_RS14025 | 3044684..3045229 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FOC65_RS14030 | 3045118..3045732 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FOC65_RS14035 | 3045781..3046077 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FOC65_RS14040 | 3046074..3046325 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FOC65_RS14045 | 3046312..3046806 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FOC65_RS14050 | 3046966..3047373 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FOC65_RS14055 | 3047377..3047649 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FOC65_RS14060 | 3047682..3048902 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FOC65_RS14065 | 3049801..3050598 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T158428 WP_003409896.1 NZ_CP054013:c3046077-3045781 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T158428 NZ_CP069636:3442279-3442566 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT158428 WP_003409899.1 NZ_CP054013:c3046325-3046074 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT158428 NZ_CP069636:3442553-3442855 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |