Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2787772..2788385 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FOC65_RS12810 Protein ID WP_003408465.1
Coordinates 2787772..2788161 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FOC65_RS12815 Protein ID WP_003408469.1
Coordinates 2788158..2788385 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS12780 2783401..2784315 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
FOC65_RS12785 2784318..2785148 + 831 WP_003916848.1 cyclase family protein -
FOC65_RS12790 2785148..2785498 + 351 WP_003898986.1 cupin domain-containing protein -
FOC65_RS12795 2785551..2786369 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FOC65_RS12800 2786383..2787162 + 780 WP_003408460.1 IclR family transcriptional regulator -
FOC65_RS12810 2787772..2788161 - 390 WP_003408465.1 PIN domain-containing protein Toxin
FOC65_RS12815 2788158..2788385 - 228 WP_003408469.1 antitoxin Antitoxin
FOC65_RS12820 2788603..2790087 + 1485 WP_003408473.1 carboxylase -
FOC65_RS12825 2790084..2791331 + 1248 WP_003408476.1 serine hydrolase -
FOC65_RS12830 2791374..2791793 - 420 WP_003408483.1 hypothetical protein -
FOC65_RS12835 2791783..2792493 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T158424 WP_003408465.1 NZ_CP054013:c2788161-2787772 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T158424 NZ_CP069636:c2447851-2447744 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT158424 WP_003408469.1 NZ_CP054013:c2788385-2788158 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT158424 NZ_CP069636:2447899-2447965 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References