Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2224813..2225501 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag FOC65_RS10310 Protein ID WP_003406304.1
Coordinates 2225070..2225501 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag FOC65_RS10305 Protein ID WP_003406302.1
Coordinates 2224813..2225073 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS10285 2220390..2221214 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
FOC65_RS10290 2221219..2222400 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
FOC65_RS10295 2222477..2223577 - 1101 WP_003916789.1 magnesium/cobalt transporter CorA -
FOC65_RS10300 2223748..2224737 + 990 WP_003406301.1 malate dehydrogenase -
FOC65_RS10305 2224813..2225073 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
FOC65_RS10310 2225070..2225501 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC65_RS10315 2225524..2227212 - 1689 WP_003910308.1 PE family protein -
FOC65_RS10320 2227392..2228252 + 861 WP_003900301.1 hypothetical protein -
FOC65_RS10325 2228333..2229163 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
FOC65_RS10330 2229220..2229513 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
FOC65_RS10335 2229510..2229779 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T158419 WP_003406304.1 NZ_CP054013:2225070-2225501 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T158419 NZ_CP069636:c739690-739439 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT158419 WP_003406302.1 NZ_CP054013:2224813-2225073 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT158419 NZ_CP069636:c739442-739188 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References