Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 1595512..1596304 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FOC65_RS07270 Protein ID WP_003403386.1
Coordinates 1595867..1596304 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag FOC65_RS07265 Protein ID WP_003403381.1
Coordinates 1595512..1595757 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS07235 1590532..1592037 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FOC65_RS07240 1592118..1593128 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FOC65_RS07245 1593516..1593899 - 384 WP_003403365.1 ribonuclease VapC6 -
FOC65_RS07250 1593994..1594149 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FOC65_RS07255 1594225..1594941 - 717 WP_010886082.1 CPBP family intramembrane metalloprotease -
FOC65_RS07260 1595217..1595525 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FOC65_RS07265 1595512..1595757 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
FOC65_RS07270 1595867..1596304 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC65_RS07275 1596301..1596555 - 255 WP_003911263.1 antitoxin VapB7 -
FOC65_RS07280 1596669..1599032 + 2364 WP_003898547.1 arylsulfatase AtsD -
FOC65_RS07285 1599095..1599421 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC65_RS07290 1599333..1599671 + 339 WP_003403405.1 PIN domain-containing protein -
FOC65_RS07295 1599668..1599841 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T158411 WP_003403386.1 NZ_CP054013:c1596304-1595867 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T158411 NZ_CP069633:4685016-4685396 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT158411 WP_003403381.1 NZ_CP054013:c1595757-1595512 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT158411 NZ_CP069633:4684595-4684969 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References