Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1593516..1594149 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag FOC65_RS07245 Protein ID WP_003403365.1
Coordinates 1593516..1593899 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag FOC65_RS07250 Protein ID WP_003403368.1
Coordinates 1593994..1594149 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS07220 1588808..1589344 + 537 WP_003403341.1 50S ribosomal protein L10 -
FOC65_RS07225 1589381..1589773 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
FOC65_RS07230 1589766..1590461 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
FOC65_RS07235 1590532..1592037 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FOC65_RS07240 1592118..1593128 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FOC65_RS07245 1593516..1593899 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
FOC65_RS07250 1593994..1594149 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC65_RS07255 1594225..1594941 - 717 WP_010886082.1 CPBP family intramembrane metalloprotease -
FOC65_RS07260 1595217..1595525 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FOC65_RS07265 1595512..1595757 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FOC65_RS07270 1595867..1596304 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FOC65_RS07275 1596301..1596555 - 255 WP_003911263.1 antitoxin VapB7 -
FOC65_RS07280 1596669..1599032 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T158409 WP_003403365.1 NZ_CP054013:c1593899-1593516 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T158409 NZ_CP069633:c3746968-3746591 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT158409 WP_003403368.1 NZ_CP054013:c1594149-1593994 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT158409 NZ_CP069633:c3747389-3747015 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References