Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1556942..1557591 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FOC65_RS07060 Protein ID WP_003403236.1
Coordinates 1557196..1557591 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FOC65_RS07055 Protein ID WP_003403235.1
Coordinates 1556942..1557196 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS07030 1552068..1552763 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FOC65_RS07035 1552760..1553251 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
FOC65_RS07040 1553248..1554339 + 1092 WP_003906403.1 galactokinase -
FOC65_RS07045 1554734..1555798 + 1065 WP_003898532.1 hypothetical protein -
FOC65_RS07050 1555902..1556849 + 948 WP_003403232.1 DUF732 domain-containing protein -
FOC65_RS07055 1556942..1557196 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FOC65_RS07060 1557196..1557591 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FOC65_RS07065 1557685..1558425 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
FOC65_RS07070 1558557..1558817 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC65_RS07075 1558814..1559221 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FOC65_RS07080 1559293..1560444 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
FOC65_RS07085 1560537..1562264 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T158407 WP_003403236.1 NZ_CP054013:1557196-1557591 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T158407 NZ_CP069633:c3510894-3510742 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT158407 WP_003403235.1 NZ_CP054013:1556942-1557196 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT158407 NZ_CP069633:3510943-3511000 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References