Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 254558..255264 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID P9WF49
Locus tag FOC65_RS01090 Protein ID WP_003917170.1
Coordinates 254854..255264 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF23
Locus tag FOC65_RS01085 Protein ID WP_003417995.1
Coordinates 254558..254857 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS01065 250568..252169 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
FOC65_RS01070 252186..252890 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
FOC65_RS01075 253008..253574 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
FOC65_RS01080 253636..254523 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
FOC65_RS01085 254558..254857 + 300 WP_003417995.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC65_RS01090 254854..255264 + 411 WP_003917170.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC65_RS01095 255297..257033 - 1737 WP_003418002.1 cholesterol oxidase -
FOC65_RS01100 257089..258216 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
FOC65_RS01105 258236..259825 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-61)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14669.76 Da        Isoelectric Point: 5.1784

>T158394 WP_003917170.1 NZ_CP054013:254854-255264 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVESMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T158394 NZ_CP069633:c398025-397923 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11009.66 Da        Isoelectric Point: 10.7399

>AT158394 WP_003417995.1 NZ_CP054013:254558-254857 [Mycobacterium tuberculosis]
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEP
ARGRKRTLSDVLNEMRDEQ

Download         Length: 300 bp

>AT158394 NZ_CP069633:397885-398153 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A5U883

Antitoxin

Source ID Structure
AlphaFold DB A0A045H9T3

References