Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 199070..199599 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FOC65_RS00830 Protein ID WP_003417760.1
Coordinates 199342..199599 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FOC65_RS00825 Protein ID WP_003417757.1
Coordinates 199070..199345 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS00790 195643..196437 - 795 WP_003417738.1 BBE domain-containing protein -
FOC65_RS00795 196519..196890 - 372 WP_003417739.1 FAD-binding oxidoreductase -
FOC65_RS00800 196788..197006 - 219 WP_157132559.1 hypothetical protein -
FOC65_RS00805 197033..197293 - 261 WP_003417741.1 hypothetical protein -
FOC65_RS00810 197408..197797 + 390 WP_003417745.1 DUF732 domain-containing protein -
FOC65_RS00815 197811..198104 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FOC65_RS00820 198101..198946 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FOC65_RS00825 199070..199345 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FOC65_RS00830 199342..199599 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FOC65_RS00835 199641..200831 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FOC65_RS00840 200948..201316 + 369 WP_003417765.1 FHA domain-containing protein -
FOC65_RS00845 201313..201864 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FOC65_RS00850 201871..202452 - 582 WP_003417769.1 ATP/GTP-binding protein -
FOC65_RS00855 202433..202801 - 369 WP_003417772.1 DUF742 domain-containing protein -
FOC65_RS00860 202779..203171 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T158392 WP_003417760.1 NZ_CP054013:199342-199599 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T158392 NZ_CP069633:c68761-68483 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT158392 WP_003417757.1 NZ_CP054013:199070-199345 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT158392 NZ_CP069633:c68483-68199 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References