Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 134213..134887 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FOC65_RS00635 Protein ID WP_003417282.1
Coordinates 134213..134641 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FOC65_RS00640 Protein ID WP_003417286.1
Coordinates 134645..134887 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS00610 130035..130436 - 402 WP_003417264.1 cytidine deaminase -
FOC65_RS00615 130577..131011 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FOC65_RS00620 131008..131442 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FOC65_RS00625 131571..133343 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FOC65_RS00630 133343..134134 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FOC65_RS00635 134213..134641 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC65_RS00640 134645..134887 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FOC65_RS00645 135009..135623 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FOC65_RS00650 135620..136285 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FOC65_RS00655 136286..136819 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FOC65_RS00660 136816..136968 - 153 WP_003916129.1 hypothetical protein -
FOC65_RS00665 137004..138265 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T158391 WP_003417282.1 NZ_CP054013:c134641-134213 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T158391 NZ_CP069631:1791-2075 [Escherichia coli]
ATGAGCTATAACCTTGAATTTGATCCCCGAGCCCTGAAGGAATGGCGCAAGCTCGGGGATGATGTCCGTCTGCAGTTCAA
GAAAAAACTCGAGCAGGTTCTACAACACCCGCGGATCGATAAAAATCGCCTGCGAGAGCTGCATGACTGCTACAAAATCA
AGCTCCGTGCATCCGGTTATCGCTTGGTCTATCAGGTTCGCGATCAAACCATTACGGTATTCGTGGTGGCGGTCGGTAAG
CGCGAGCGTTCTGCCGCTTACGATGCGGCCGATAAACGCTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT158391 WP_003417286.1 NZ_CP054013:c134887-134645 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT158391 NZ_CP069631:1559-1801 [Escherichia coli]
ATGGCCACGATTAATATTCGGATCGATGACGAGCTGAAAAGCCGCTCTTATGCCGCACTGGAAAAGCTGGGCGTAACGCC
GTCCGAGGTTCTGCGCCAAACACTGGAATATGTGGCCCAAAGCGGACGTTTGCCGTTCCAGCAGGTTTTGCTGACCGAGG
ATGATGCCGATTTGATGGCTATCGTTCGGGATCGTCTGGAAAACCCACAGGCGGGCGTAAAGGTGTCACTGGATGAGCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References