Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1183195..1183713 Replicon chromosome
Accession NZ_CP054006
Organism Staphylococcus hominis strain FDAARGOS_762

Toxin (Protein)


Gene name TsdT Uniprot ID A0A6B8SK15
Locus tag FOC68_RS06065 Protein ID WP_002448674.1
Coordinates 1183195..1183404 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag FOC68_RS06070 Protein ID WP_002437530.1
Coordinates 1183420..1183713 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC68_RS06045 1178785..1180140 - 1356 WP_002448671.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FOC68_RS06050 1180156..1181226 - 1071 WP_002448652.1 D-alanine--D-alanine ligase -
FOC68_RS06055 1181600..1182784 + 1185 WP_002448689.1 rod shape-determining protein RodA -
FOC68_RS06060 1182945..1183082 - 138 WP_002437525.1 hypothetical protein -
FOC68_RS06065 1183195..1183404 - 210 WP_002448674.1 heavy-metal-associated domain-containing protein Toxin
FOC68_RS06070 1183420..1183713 - 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
FOC68_RS06075 1183879..1185363 + 1485 WP_002448646.1 cardiolipin synthase -
FOC68_RS06080 1185398..1186045 + 648 WP_002448635.1 HD domain-containing protein -
FOC68_RS06085 1186103..1186972 - 870 WP_002448693.1 membrane protein insertase YidC -
FOC68_RS06090 1187061..1187699 - 639 WP_002448695.1 thiamine phosphate synthase -
FOC68_RS06095 1187702..1188490 - 789 WP_002448660.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7956.00 Da        Isoelectric Point: 4.0857

>T158390 WP_002448674.1 NZ_CP054006:c1183404-1183195 [Staphylococcus hominis]
MLNSNIVFIDNIETEEQAQMLNERLLNMIGVHTVSIDIERNKINVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T158390 NZ_CP069630:c4881537-4881430 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT158390 WP_002437530.1 NZ_CP054006:c1183713-1183420 [Staphylococcus hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT158390 NZ_CP069630:4881593-4881654 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B8SK15

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References