Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1172169..1172698 Replicon chromosome
Accession NZ_CP054006
Organism Staphylococcus hominis strain FDAARGOS_762

Toxin (Protein)


Gene name mazF Uniprot ID A0A657ZQB6
Locus tag FOC68_RS06005 Protein ID WP_002448688.1
Coordinates 1172169..1172531 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag FOC68_RS06010 Protein ID WP_002448681.1
Coordinates 1172528..1172698 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC68_RS05985 1169158..1169928 - 771 WP_002448709.1 RNA polymerase sigma factor SigB -
FOC68_RS05990 1169903..1170382 - 480 WP_002448683.1 anti-sigma B factor RsbW -
FOC68_RS05995 1170384..1170710 - 327 WP_002448686.1 anti-sigma factor antagonist -
FOC68_RS06000 1170796..1171797 - 1002 WP_002448679.1 PP2C family protein-serine/threonine phosphatase -
FOC68_RS06005 1172169..1172531 - 363 WP_002448688.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FOC68_RS06010 1172528..1172698 - 171 WP_002448681.1 hypothetical protein Antitoxin
FOC68_RS06015 1172784..1173929 - 1146 WP_002448692.1 alanine racemase -
FOC68_RS06020 1173972..1174325 - 354 WP_002448655.1 holo-ACP synthase -
FOC68_RS06025 1174353..1174829 - 477 WP_002448662.1 PH domain-containing protein -
FOC68_RS06030 1174822..1176324 - 1503 WP_002448703.1 PH domain-containing protein -
FOC68_RS06035 1176314..1176793 - 480 WP_002448666.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13527.69 Da        Isoelectric Point: 9.3701

>T158389 WP_002448688.1 NZ_CP054006:c1172531-1172169 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVCPQKN

Download         Length: 363 bp

>T158389 NZ_CP069630:4685017-4685397 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT158389 WP_002448681.1 NZ_CP054006:c1172698-1172528 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT158389 NZ_CP069630:4684596-4684970 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A657ZQB6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References