Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1042490..1043285 Replicon chromosome
Accession NZ_CP054006
Organism Staphylococcus hominis strain FDAARGOS_762

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag FOC68_RS05225 Protein ID WP_002449670.1
Coordinates 1042490..1042657 (-) Length 56 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag FOC68_RS05230 Protein ID WP_002449669.1
Coordinates 1042686..1043285 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC68_RS05200 1037675..1038298 - 624 WP_002449659.1 response regulator transcription factor -
FOC68_RS05205 1038313..1039422 - 1110 WP_002449621.1 GAF domain-containing sensor histidine kinase -
FOC68_RS05210 1039560..1040384 + 825 WP_002449623.1 RluA family pseudouridine synthase -
FOC68_RS05215 1040463..1041848 - 1386 WP_002449635.1 class II fumarate hydratase -
FOC68_RS05220 1041987..1042379 - 393 WP_002449658.1 hypothetical protein -
FOC68_RS05225 1042490..1042657 - 168 WP_002449670.1 hypothetical protein Toxin
FOC68_RS05230 1042686..1043285 - 600 WP_002449669.1 glucosamine-6-phosphate isomerase Antitoxin
FOC68_RS05235 1043445..1043915 - 471 WP_002449676.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
FOC68_RS05240 1043917..1045038 - 1122 WP_002449664.1 tRNA epoxyqueuosine(34) reductase QueG -
FOC68_RS05245 1045300..1046022 - 723 WP_002449645.1 amino acid ABC transporter ATP-binding protein -
FOC68_RS05250 1046015..1047469 - 1455 WP_002449653.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6477.82 Da        Isoelectric Point: 4.0410

>T158388 WP_002449670.1 NZ_CP054006:c1042657-1042490 [Staphylococcus hominis]
MSKDSKRNYHEDENAMVQNMNDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Download         Length: 168 bp

>T158388 NZ_CP069630:c4039655-4039437 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22389.25 Da        Isoelectric Point: 4.9712

>AT158388 WP_002449669.1 NZ_CP054006:c1043285-1042686 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNTGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT158388 NZ_CP069630:c4040055-4039681 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References