Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii(toxin)
Location 1916310..1917735 Replicon chromosome
Accession NZ_CP054000
Organism Finegoldia magna strain FDAARGOS_764

Toxin (Protein)


Gene name abiEi Uniprot ID A0A7D4FM72
Locus tag FOC70_RS09275 Protein ID WP_002842348.1
Coordinates 1916310..1917149 (-) Length 280 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A7D4FIN7
Locus tag FOC70_RS09280 Protein ID WP_002842321.1
Coordinates 1917142..1917735 (-) Length 198 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC70_RS09265 1913695..1914255 - 561 WP_002842333.1 type III toxin-antitoxin system ToxN/AbiQ family toxin -
FOC70_RS09270 1914534..1916240 - 1707 WP_002842318.1 DNA topoisomerase 3 -
FOC70_RS09275 1916310..1917149 - 840 WP_002842348.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FOC70_RS09280 1917142..1917735 - 594 WP_002842321.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
FOC70_RS09285 1918050..1918928 - 879 WP_002842351.1 DUF4366 domain-containing protein -
FOC70_RS09290 1918944..1921295 - 2352 WP_002842319.1 leucine-rich repeat protein -
FOC70_RS09295 1921282..1921521 - 240 WP_001080402.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1906666..1965166 58500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-266)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 280 a.a.        Molecular weight: 32412.49 Da        Isoelectric Point: 7.7874

>T158387 WP_002842348.1 NZ_CP054000:c1917149-1916310 [Finegoldia magna]
MNKAKLTAICHNISKESGLPFNSVMLYYFLESILKKLAQSKYHEKFIFKGGFLLSNVVGIDSRSTVDIDLLLRNMHLSEE
NVLKTIQELLEASHSDDISYKVNGISTIKEDDQYGGFRVSILCRMENIRQIVPLDIATGDVITPHPIDYKYISAFGQEDI
LIKAYPIETIVAEKIQTIYSRGFLNSRSKDYYDLYIIYKLKDKEVDTKILKEACIRTFDYRKTELDIDKIISLMRMLKTD
QAFLERWNSYSKKNLYARDIKFEDVINNGINIIEKIKNQ

Download         Length: 840 bp

>T158387 NZ_CP069630:c3746969-3746592 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 198 a.a.        Molecular weight: 23474.05 Da        Isoelectric Point: 8.6736

>AT158387 WP_002842321.1 NZ_CP054000:c1917735-1917142 [Finegoldia magna]
MNYRKQIEIHLKESGGIITSAYCRENNIPTVYLSRLAKEGKLFRVQKGIYIIEDGDFDEYYFFQYQYGKAIFSYETALFL
LGVTDKIPWRIDVTVYNGYKFNEKQDTLNINYVKKSIYNLGIIQKKTMFGNIVNVYSYERILCDFISNKEKMDTEVYVKL
IRSYSKYKDKDIHSLYEIARKMGIEDKVREVMEVVYE

Download         Length: 594 bp

>AT158387 NZ_CP069630:c3747390-3747016 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D4FM72

Antitoxin

Source ID Structure
AlphaFold DB A0A7D4FIN7

References