Detailed information of TA system TA158386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 266993..267601
• Replicon: chromosome
• Accession: NZ_CP053999
• Organism: Streptococcus intermedius strain FDAARGOS_769

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I0S7M8
• Locus tag: FOC71_RS01430
• Protein ID: WP_003038349.1
• Coordinates: 266993..267184 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: I0S7P0
• Locus tag: FOC71_RS01435
• Protein ID: WP_003038371.1
• Coordinates: 267221..267601 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC71_RS01385	262298..262465	+	168	WP_003075312.1	hypothetical protein	-
FOC71_RS01390	262808..263086	+	279	WP_003027794.1	hypothetical protein	-
FOC71_RS01395	263083..263259	+	177	WP_003027795.1	hypothetical protein	-
FOC71_RS01400	263249..263485	+	237	WP_003075314.1	hypothetical protein	-
FOC71_RS01405	263482..263817	+	336	WP_003075316.1	hypothetical protein	-
FOC71_RS01410	263819..264088	+	270	WP_003075318.1	hypothetical protein	-
FOC71_RS01415	264097..264909	+	813	WP_003075320.1	phage replisome organizer N-terminal domain-containing protein	-
FOC71_RS01420	264924..265775	+	852	WP_003075322.1	ATP-binding protein	-
FOC71_RS01425	266024..266464	+	441	Protein_267	ArpU family transcriptional regulator	-
FOC71_RS01430	266993..267184	+	192	WP_003038349.1	type II toxin-antitoxin system HicA family toxin	Toxin
FOC71_RS01435	267221..267601	+	381	WP_003038371.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FOC71_RS01440	268140..268580	+	441	WP_003075326.1	LytTR family transcriptional regulator	-
FOC71_RS01445	268577..269035	+	459	WP_003075329.1	DUF3021 domain-containing protein	-
FOC71_RS01450	269177..271735	-	2559	WP_003075333.1	DNA mismatch repair protein MutS	-
FOC71_RS01455	271898..272338	-	441	WP_003075336.1	arginine repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	254286..267601	13315

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7192.29 Da
• Isoelectric Point: 8.6749

>T158386 WP_003038349.1 NZ_CP053999:266993-267184 [Streptococcus intermedius]
MPLTGKEMAKLAEKNGWVEIRQNGSHHHFKHEDFDYIVTIPIHGNKDLGRGLESKILKDLGLK

Nucleotide

• Length: 192 bp

>T158386 NZ_CP069630:3547830-3548144 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14150.14 Da
• Isoelectric Point: 4.5235

>AT158386 WP_003038371.1 NZ_CP053999:267221-267601 [Streptococcus intermedius]
MLKSYPAIFHKEEDGSYWVEFPEFGGGTQGANVEEALKNAREMLESVLAAYIDEGLDMPKPSDIMALTVKDGFVSMIQAD
PTPFIRNNKAVRKNVTVPEWLVRLADREKVNYSEVLTQALETKLQA

Nucleotide

• Length: 381 bp

>AT158386 NZ_CP069630:3547594-3547827 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: I0S7M8

Antitoxin

• AlphaFold DB: I0S7P0