Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 810407..811382 Replicon chromosome
Accession NZ_CP053997
Organism Bacillus cereus strain FDAARGOS_780

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag FOC74_RS05955 Protein ID WP_002036394.1
Coordinates 810645..811382 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC74_RS05950 Protein ID WP_000588712.1
Coordinates 810407..810532 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC74_RS05920 806110..806730 - 621 WP_002036390.1 SGNH/GDSL hydrolase family protein -
FOC74_RS05925 806907..807377 + 471 WP_000670597.1 DUF5065 family protein -
FOC74_RS05930 807612..809081 - 1470 WP_000287523.1 beta-Ala-His dipeptidase -
FOC74_RS05935 809225..809401 - 177 WP_000808045.1 hypothetical protein -
FOC74_RS05940 809836..810117 + 282 WP_001041555.1 hypothetical protein -
FOC74_RS05945 810154..810330 - 177 WP_000852612.1 hypothetical protein -
FOC74_RS05950 810407..810532 - 126 WP_000588712.1 hypothetical protein Antitoxin
FOC74_RS05955 810645..811382 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC74_RS05960 811571..812308 - 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC74_RS05965 812476..812958 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC74_RS05970 813065..814750 + 1686 WP_002036395.1 alpha-keto acid decarboxylase family protein -
FOC74_RS05975 814872..815182 - 311 Protein_830 hypothetical protein -
FOC74_RS05980 815443..815850 - 408 WP_000072501.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T158384 WP_002036394.1 NZ_CP053997:c811382-810645 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T158384 NZ_CP069630:3442280-3442567 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT158384 WP_000588712.1 NZ_CP053997:c810532-810407 [Bacillus cereus]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT158384 NZ_CP069630:3442554-3442856 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References