Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1866558..1867533 Replicon chromosome
Accession NZ_CP053991
Organism Bacillus cereus strain FDAARGOS_781

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag FOC75_RS10135 Protein ID WP_002036394.1
Coordinates 1866558..1867295 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC75_RS10140 Protein ID WP_000588712.1
Coordinates 1867408..1867533 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC75_RS10110 1862090..1862497 + 408 WP_000072501.1 VOC family protein -
FOC75_RS10115 1862758..1863068 + 311 Protein_1899 hypothetical protein -
FOC75_RS10120 1863190..1864875 - 1686 WP_002036395.1 alpha-keto acid decarboxylase family protein -
FOC75_RS10125 1864982..1865464 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC75_RS10130 1865632..1866369 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC75_RS10135 1866558..1867295 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC75_RS10140 1867408..1867533 + 126 WP_000588712.1 hypothetical protein Antitoxin
FOC75_RS10145 1867610..1867786 + 177 WP_000852612.1 hypothetical protein -
FOC75_RS10150 1867823..1868104 - 282 WP_001041555.1 hypothetical protein -
FOC75_RS10155 1868539..1868715 + 177 WP_000808045.1 hypothetical protein -
FOC75_RS10160 1868859..1870328 + 1470 WP_000287523.1 beta-Ala-His dipeptidase -
FOC75_RS10165 1870563..1871033 - 471 WP_000670597.1 DUF5065 family protein -
FOC75_RS10170 1871210..1871830 + 621 WP_002036390.1 SGNH/GDSL hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T158382 WP_002036394.1 NZ_CP053991:1866558-1867295 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T158382 NZ_CP069630:3172061-3172234 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT158382 WP_000588712.1 NZ_CP053991:1867408-1867533 [Bacillus cereus]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT158382 NZ_CP069630:3171737-3172033 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References