Detailed information of TA system TA158378

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 4184724..4185385
• Replicon: chromosome
• Accession: NZ_CP053987
• Organism: Achromobacter denitrificans strain FDAARGOS_786

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3R9GKR9
• Locus tag: FOC80_RS19575
• Protein ID: WP_062682299.1
• Coordinates: 4184724..4185137 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOC80_RS19580
• Protein ID: WP_062682298.1
• Coordinates: 4185134..4185385 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC80_RS19550	4179767..4180366	-	600	WP_062682301.1	C40 family peptidase	-
FOC80_RS19555	4180699..4182195	+	1497	WP_062682325.1	AMP nucleosidase	-
FOC80_RS19560	4182426..4183910	+	1485	WP_062682324.1	amino acid permease	-
FOC80_RS19565	4183820..4184497	-	678	WP_082775793.1	FecR family protein	-
FOC80_RS19570	4184506..4184715	-	210	WP_131828769.1	hypothetical protein	-
FOC80_RS19575	4184724..4185137	-	414	WP_062682299.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC80_RS19580	4185134..4185385	-	252	WP_062682298.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOC80_RS19585	4185526..4185834	+	309	WP_131828768.1	hypothetical protein	-
FOC80_RS19590	4185892..4186821	-	930	WP_062682323.1	YicC family protein	-
FOC80_RS19595	4187023..4187742	+	720	WP_172600300.1	ribonuclease PH	-
FOC80_RS19600	4188051..4189448	+	1398	WP_082775797.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-64)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15466.80 Da
• Isoelectric Point: 5.2418

>T158378 WP_062682299.1 NZ_CP053987:c4185137-4184724 [Achromobacter denitrificans]
MSYLVDTNVLSELRRKQPDGNVVRWLEQRPATTLFLSALTMGELRKGIELMPEGERKRSYLDWLEVELPRFFSGRVLAID
EPVADCWGRLVAQAGRALPAIDSLLAATALAHGLTLVTRNERDFQHPGLDVINPWEV

Nucleotide

• Length: 414 bp

>T158378 NZ_CP069630:1802210-1802587 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9054.16 Da
• Isoelectric Point: 5.0760

>AT158378 WP_062682298.1 NZ_CP053987:c4185385-4185134 [Achromobacter denitrificans]
MHVWQMQEAKSRLSEVVKAAGTQGPQEITVHGRSVAVVLSRADFDKLSGTGESLVAFMRRSPLAGDEDLAFPRDDSPTRE
EGL

Nucleotide

• Length: 252 bp

>AT158378 NZ_CP069630:1801753-1802121 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: A0A3R9GKR9