Detailed information of TA system TA158377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 6651607..6653273
• Replicon: chromosome
• Accession: NZ_CP053986
• Organism: Achromobacter denitrificans strain FDAARGOS_788

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FOC82_RS30840
• Protein ID: WP_062683046.1
• Coordinates: 6652434..6653273 (-)
• Length: 280 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: FOC82_RS30835
• Protein ID: WP_062683047.1
• Coordinates: 6651607..6652422 (-)
• Length: 272 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC82_RS30815	6646791..6648278	-	1488	WP_062683051.1	aldehyde dehydrogenase	-
FOC82_RS30820	6648286..6649083	-	798	WP_062683050.1	aspartate dehydrogenase	-
FOC82_RS30825	6649091..6650761	-	1671	WP_062683049.1	thiamine pyrophosphate-binding protein	-
FOC82_RS30830	6650754..6651545	-	792	WP_062683048.1	SDR family oxidoreductase	-
FOC82_RS30835	6651607..6652422	-	816	WP_062683047.1	IclR family transcriptional regulator	Antitoxin
FOC82_RS30840	6652434..6653273	-	840	WP_062683046.1	alpha/beta hydrolase	Toxin
FOC82_RS30845	6653426..6654481	+	1056	WP_062683045.1	porin	-
FOC82_RS30850	6654576..6655166	+	591	WP_062683070.1	cupin domain-containing protein	-
FOC82_RS30855	6655212..6656213	+	1002	WP_062683044.1	ABC transporter substrate-binding protein	-
FOC82_RS30860	6656206..6656994	+	789	WP_075873250.1	ABC transporter ATP-binding protein	-
FOC82_RS30865	6656996..6657754	+	759	WP_075873249.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (39-270)

Antitoxin

• Transcription regulator IclR, C-terminal (138-260)

Sequences

Toxin

Protein

• Length: 280 a.a.
• Molecular weight: 29151.29 Da
• Isoelectric Point: 7.8874

>T158377 WP_062683046.1 NZ_CP053986:c6653273-6652434 [Achromobacter denitrificans]
MPATEQAMRDQALHRFTACLAPTAQGPSAYRRLGTGPAVVLLHGIGSGSGCWLDAATALAGECTVLAWDAPGYGASAPLA
GDRPSAADYAERLHQVLRHAGIDECVLVGHSLGALVAAAYCARRERARISRLVLLSPARGYGSADAGEREATRGKRLGAL
ERLGIDGMAAARASALLSPAAQAGQVQWAAWNMRQITPEGYRQAVGLLCDGDLLAFPVPPMSVDVRVGIHDTITPAPKCQ
AIAAAWRASFELIPGAGHACHIERPQEVAEIVRQARAGS

Nucleotide

• Length: 840 bp

>T158377 NZ_CP069630:c1661140-1660733 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 272 a.a.
• Molecular weight: 29497.47 Da
• Isoelectric Point: 6.0246

>AT158377 WP_062683047.1 NZ_CP053986:c6652422-6651607 [Achromobacter denitrificans]
MSDTDVNDDGRDRYTVPALERGLRLLCQFNRNDRALGAPELARRLDLPRSTVFRMLNTLEHMGFVRKTDGGSTYQLDMGV
LRLGFEYLASLELTELGRPLLERVRDATGYPSNLVVLDQHWAVVVAKSSAPTPFVSTVYVGTRLPAHATLLGRALLCDLS
LDALRNLYGDAPLQSYSPRTPGTVEALHEVLQQDRARGYVSDHGFYEAAVASIAAPVRDRNGATVAALGVTIPTMTTTQP
AMDEAGVIATVRSAADELSRLLDYAPPGATR

Nucleotide

• Length: 816 bp

>AT158377 NZ_CP069630:c1661387-1661121 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA