Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1668073..1668734 Replicon chromosome
Accession NZ_CP053986
Organism Achromobacter denitrificans strain FDAARGOS_788

Toxin (Protein)


Gene name vapC Uniprot ID A0A3R9GKR9
Locus tag FOC82_RS07580 Protein ID WP_062682299.1
Coordinates 1668321..1668734 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOC82_RS07575 Protein ID WP_062682298.1
Coordinates 1668073..1668324 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC82_RS07555 1664010..1665407 - 1398 WP_082775797.1 aldehyde dehydrogenase family protein -
FOC82_RS07560 1665716..1666435 - 720 WP_172600300.1 ribonuclease PH -
FOC82_RS07565 1666637..1667566 + 930 WP_062682323.1 YicC family protein -
FOC82_RS07570 1667624..1667932 - 309 WP_131828768.1 hypothetical protein -
FOC82_RS07575 1668073..1668324 + 252 WP_062682298.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC82_RS07580 1668321..1668734 + 414 WP_062682299.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC82_RS07585 1668743..1668952 + 210 WP_131828769.1 hypothetical protein -
FOC82_RS07590 1668961..1669638 + 678 WP_082775793.1 FecR family protein -
FOC82_RS07595 1669548..1671032 - 1485 WP_062682324.1 amino acid permease -
FOC82_RS07600 1671263..1672759 - 1497 WP_062682325.1 AMP nucleosidase -
FOC82_RS07605 1673092..1673691 + 600 WP_062682301.1 C40 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15466.80 Da        Isoelectric Point: 5.2418

>T158376 WP_062682299.1 NZ_CP053986:1668321-1668734 [Achromobacter denitrificans]
MSYLVDTNVLSELRRKQPDGNVVRWLEQRPATTLFLSALTMGELRKGIELMPEGERKRSYLDWLEVELPRFFSGRVLAID
EPVADCWGRLVAQAGRALPAIDSLLAATALAHGLTLVTRNERDFQHPGLDVINPWEV

Download         Length: 414 bp

>T158376 NZ_CP069630:c1445824-1445513 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9054.16 Da        Isoelectric Point: 5.0760

>AT158376 WP_062682298.1 NZ_CP053986:1668073-1668324 [Achromobacter denitrificans]
MHVWQMQEAKSRLSEVVKAAGTQGPQEITVHGRSVAVVLSRADFDKLSGTGESLVAFMRRSPLAGDEDLAFPRDDSPTRE
EGL

Download         Length: 252 bp

>AT158376 NZ_CP069630:c1445516-1445097 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATACCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9GKR9

Antitoxin

Source ID Structure

References