Detailed information of TA system TA158375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 6925347..6926028
• Replicon: chromosome
• Accession: NZ_CP053985
• Organism: Achromobacter pestifer strain FDAARGOS_790

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FOC84_RS32555
• Protein ID: WP_119449491.1
• Coordinates: 6925843..6926028 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FOC84_RS32550
• Protein ID: WP_173149634.1
• Coordinates: 6925347..6925766 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC84_RS32540	6922360..6923709	-	1350	WP_173149630.1	mechanosensitive ion channel	-
FOC84_RS32545	6923846..6925264	+	1419	WP_173149632.1	argininosuccinate lyase	-
FOC84_RS32550	6925347..6925766	-	420	WP_173149634.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FOC84_RS32555	6925843..6926028	-	186	WP_119449491.1	type II toxin-antitoxin system HicA family toxin	Toxin
FOC84_RS32560	6926191..6927099	-	909	WP_173149636.1	LysR family transcriptional regulator	-
FOC84_RS32565	6927207..6928400	+	1194	WP_173149638.1	MFS transporter	-
FOC84_RS32570	6928504..6929313	-	810	WP_173149640.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-70)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7052.15 Da
• Isoelectric Point: 10.6654

>T158375 WP_119449491.1 NZ_CP053985:c6926028-6925843 [Achromobacter pestifer]
MKYSEFKRWLERQGAVFVPHKSGSSHYRVTLNGVTTIFPHHGSKEMGKHLESEIKKQLGLK

Nucleotide

• Length: 186 bp

>T158375 NZ_CP069630:c739690-739439 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15411.73 Da
• Isoelectric Point: 5.2252

>AT158375 WP_173149634.1 NZ_CP053985:c6925766-6925347 [Achromobacter pestifer]
MLTYPYTLTRDTNDTWLVQFPDIPEALTVGQDADEAAINAEEALEAALEIYFEARRPIPMPSKPAKGQASVTLPALVTSK
VFLSNEMILQGVRKAELARRMGVHMPQVDRLLNVRHASRIEQVESALGQLGRRLDVSIA

Nucleotide

• Length: 420 bp

>AT158375 NZ_CP069630:c739442-739188 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA