Detailed information of TA system TA158373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 3214084..3215531
• Replicon: chromosome
• Accession: NZ_CP053985
• Organism: Achromobacter pestifer strain FDAARGOS_790

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: FOC84_RS15580
• Protein ID: WP_173145202.1
• Coordinates: 3214680..3215531 (+)
• Length: 284 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: FOC84_RS15575
• Protein ID: WP_173145201.1
• Coordinates: 3214084..3214683 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC84_RS15540	3209452..3210027	+	576	WP_173145196.1	hypothetical protein	-
FOC84_RS15545	3210065..3210970	-	906	WP_082401233.1	DMT family transporter	-
FOC84_RS15550	3211014..3211658	-	645	WP_173145197.1	LysE family translocator	-
FOC84_RS15555	3211850..3212311	+	462	WP_173145198.1	Lrp/AsnC family transcriptional regulator	-
FOC84_RS15560	3212430..3212957	+	528	WP_173145199.1	DUF4142 domain-containing protein	-
FOC84_RS15565	3212920..3213318	+	399	WP_173145200.1	cupredoxin family copper-binding protein	-
FOC84_RS15570	3213340..3214044	+	705	WP_173150173.1	RNA polymerase sigma factor	-
FOC84_RS15575	3214084..3214683	+	600	WP_173145201.1	AbiEi antitoxin N-terminal domain-containing protein	Antitoxin
FOC84_RS15580	3214680..3215531	+	852	WP_173145202.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FOC84_RS15585	3215559..3217946	-	2388	WP_173145203.1	copper-translocating P-type ATPase	-
FOC84_RS15590	3218074..3218469	-	396	WP_173145204.1	hypothetical protein	-
FOC84_RS15595	3218677..3219444	-	768	WP_173145205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (37-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-51)

Sequences

Toxin

Protein

• Length: 284 a.a.
• Molecular weight: 31725.74 Da
• Isoelectric Point: 7.2455

>T158373 WP_173145202.1 NZ_CP053985:3214680-3215531 [Achromobacter pestifer]
MTVARNIAASVRARLLNKARADKQNFNLLLTRYALERILYRLSISPYREQFLLKGSLLFDLWFDMPHRPTHDADLLGFTL
AEVPHLMAVFQEISAIACEDGMTFPPESVRAAEIRKEANYAGIRVNLAGSLDGARCPVQIDIGFGDAVVPGPEEAQYPVI
FGDMPAPRLQVYPQYTVIAEKLEAIVSLGMGNTRMKDYFDLWVMARRAELDDGMLARAVRATFARRETPAPADFPLGLAD
EFVQDERKVQQWDAFLRKNGLAKVSLNEAVGAIRPLWLAAMKK

Nucleotide

• Length: 852 bp

>T158373 NZ_CP069630:727100-727474 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22069.73 Da
• Isoelectric Point: 10.7641

>AT158373 WP_173145201.1 NZ_CP053985:3214084-3214683 [Achromobacter pestifer]
MTSATEKLLALAREEGLIRARDLAPQGIARVTLTRAVRQGQLQRVGRGLYGLSSRRISEHATLAETARRVPKGVICLLSA
LRFHGLTTQAPREVWLAIGNKAAAPKLDYPPLRVLRFSTSALAAGVEEHVADGVPIHVTGVAKTVADCFKFRNKIGLDVA
LEALREAWREKRMTSDEMWRYAKLCRVANVMRPYLESLE

Nucleotide

• Length: 600 bp

>AT158373 NZ_CP069630:726643-727011 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA