Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3269921..3270896 Replicon chromosome
Accession NZ_CP053981
Organism Bacillus thuringiensis strain FDAARGOS_793

Toxin (Protein)


Gene name spoIISA Uniprot ID C2NHW3
Locus tag FOC87_RS16850 Protein ID WP_002002796.1
Coordinates 3269921..3270658 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC87_RS16855 Protein ID WP_000588712.1
Coordinates 3270771..3270896 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC87_RS16825 3265413..3266114 + 702 WP_001294994.1 hypothetical protein -
FOC87_RS16830 3266242..3267126 + 885 WP_000795513.1 hypothetical protein -
FOC87_RS16835 3267419..3268238 - 820 Protein_3217 alpha-keto acid decarboxylase family protein -
FOC87_RS16840 3268345..3268827 + 483 WP_000191909.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC87_RS16845 3268995..3269732 + 738 WP_000594157.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC87_RS16850 3269921..3270658 + 738 WP_002002796.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC87_RS16855 3270771..3270896 + 126 WP_000588712.1 hypothetical protein Antitoxin
FOC87_RS16860 3271170..3271451 - 282 WP_001041559.1 hypothetical protein -
FOC87_RS16865 3271731..3271967 - 237 WP_001021690.1 hypothetical protein -
FOC87_RS16870 3272306..3272482 + 177 WP_000852618.1 hypothetical protein -
FOC87_RS16875 3272626..3274095 + 1470 WP_000287551.1 beta-Ala-His dipeptidase -
FOC87_RS16880 3274681..3275151 - 471 WP_000771846.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28283.98 Da        Isoelectric Point: 8.2998

>T158370 WP_002002796.1 NZ_CP053981:3269921-3270658 [Bacillus thuringiensis]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNAAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTTFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T158370 NZ_CP069630:c68761-68483 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT158370 WP_000588712.1 NZ_CP053981:3270771-3270896 [Bacillus thuringiensis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT158370 NZ_CP069630:c68483-68199 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D3YFM0

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References